Molecular Iodine Mediated One-Pot Three-Component Reaction for Synthesis of Thiadiazolo [2, 3-b] Quinozolin-6(7H)-ones and their Antimicrobial Activity

Angulwar, Jaman A.; Khansole, Gopinath S.; Bhosale, Vijay N.

doi:10.22034/jsc.2022.155236

Molecular Iodine Mediated One-Pot Three-Component Reaction for Synthesis of Thiadiazolo [2, 3-b] Quinozolin-6(7H)-ones and their Antimicrobial Activity

Document Type : Original Research

Authors

¹ P.G. Department of Chemistry, Dayanand Science College, Latur (M.S.) India.

² P.G. Department of Chemistry, D. A. B. N. Arts and Science College, Chikhali, Sangli (M.S.) India.

³ P. G. Department of Chemistry, Yeshwant Mahavidyalaya, Nanded, (M.S.) India -431602

10.22034/jsc.2022.155236

Abstract

Thiadiazolo [2,3-b] quinazolinone derivatives are significantly synthesized by one-pot manner. Herein, we describe a three-component reaction system of 5-aryl-1,3,4-thiadiazolo-2amine, dimedone moiety and substituted aromatic aldehyde with a massive addition of molecular iodine. Interestingly, in present work, we focused on more efficient and convenient synthesis, such as easy isolation of compound, mild conditions and excellent yield. All synthesized compounds are characterized by spectral analysis and further ahead for their antimicrobial activity.

Graphical Abstract