Surfactant TBAB as a Catalyst for the Synthesis of 3, 4-Dihydropyrimidine Derivatives

Document Type : Original Research

Authors

1 Department of Organic Chemistry, Mashhad Azad University.

2 School of Chemistry and Inorganic chemistry, Mashhad Azad University.

Abstract

3, 4-Dihydropyrimidine compounds are widely used in the pharmaceutical industry due to their biological, antibacterial, antiviral, anti-HIV and anti-tumor properties and other medicinal properties, and therefore, considering the practical importance of these compounds, providing new synthetic methods and synthesis New derivatives of them are necessary. In this research, the synthesis of new derivatives of these compounds using tetrabutylammonium bromide (TBAB) surfactant as a green and environmentally friendly catalyst is reported. From the condensation of β-dicarbonyl with urea or thiourea and aromatic aldehydes in the presence of catalyst TBAB at 80°C in solvent-free conditions, new dihydropyrimidine derivatives were substituted. The structure of the synthesized compounds was confirmed using spectroscopic data. The features of this method include high efficiency, mild conditions, single container, not need for solvent, and compatibility of the catalyst with the environment.

Graphical Abstract

Surfactant TBAB as a Catalyst for the Synthesis of 3, 4-Dihydropyrimidine Derivatives

Keywords