Synthesis of Polyhydroquinoline Derivatives in the Presence of Nanoboehmite by Hantzsch Reaction

Document Type : Original Research

Authors

1 School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China

2 School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, P. R. China.

Abstract

Polyhydroquinolines are drugs with various biological properties, including calcium channel blocker, antitumor, antidiabetic, and heart and blood vessel dilator. In this research, various derivatives of polyhydroquinolines were synthesized using nanoboehmite as a catalyst. From the partial reaction of ammonium acetate with aromatic aldehydes, ethyl acetoacetate and dimedone in the presence of nanoboehmite as a catalyst in solvent-free conditions and at temperature of 60 poly derivatives Substituted hydroquinolines were synthesized in short times with excellent yields. The catalyst used is non-toxic and cheap. The structure of the synthesized compounds was confirmed using spectroscopic data. The characteristics of this method are high yield, simple and mild reaction conditions, single container, no need for solvent, use of non-toxic materials, cheap and compatible with the environment and easy separation of the products.

Graphical Abstract

Synthesis of Polyhydroquinoline Derivatives in the Presence of Nanoboehmite by Hantzsch Reaction

Keywords