SDBS is Highly Alternative as a Green and Efficient Catalyst for the One-Pot Four-Component Synthesis of Imidazole Derivatives

Document Type : Original Research

Authors

1 Faculty of Chemical Sciences, Complutense University of Madrid, Spain

2 Faculty of Basic Sciences, Department of Chemical Chemistry, Complutense University of Madrid, Spain

Abstract

Imidazoles are drugs with various biological properties such as antifungal, anti-inflammatory, analgesic, anti-tuberculosis, anti-depressant, anti-cancer and anti-viral. In this research, new derivatives of imidazoles were synthesized using anionic surfactant SDBS as a catalyst From the four-component and three-component reaction of benzyl with aromatic benzaldehydes and first-type aliphatic and aromatic amines and ammonium acetate in the presence of SDBS as a catalyst in solvent-free conditions and at a temperature of 80 °C, derivatives of tetrasubstituted was synthesized with high yield. The structure of the synthesized compounds was confirmed using spectroscopic data. Among the features of this method are high yield, simple and mild conditions, one-pot reaction and no need for solvent.

Graphical Abstract

SDBS is Highly Alternative as a Green and Efficient Catalyst for the One-Pot Four-Component Synthesis of Imidazole Derivatives

Keywords