Magnetic Nanoparticles Functionalized with Benzo[d]oxazole as an Efficient and Recyclable Magnetic Catalyst for the Synthesis of 1,4-dihydropyridine Derivatives from Barbituric Acid

Document Type : Original Research

Authors

1 Department of Analytical chemistry, Mexico University, Mexico

2 Department of Organic Chemistry, National Autonomous University of Mexico.

Abstract

1,4-dihydropyridines have a wide range of biological and medical effects and play an important role in the construction of natural products and drugs. These compounds form a group of drugs used to treat cardiovascular diseases. These compounds have biological effects such as bronchodilator, antidiabetic, antianginal, anti-AIDS, anticancer, blood pressure lowering, liver protective, etc. The synthesis of these compounds has attracted great attentionand therefore various methods for their preparation have been described. The main goal of the research was to obtain new 1,4-dihydropyridine derivatives in the presence of the Fe3O4@benzo[d]oxazole@Mn catalyst. In the first step, the catalyst was prepared and then the one-pot four-component reaction between barbituric acid, aromatic aldehydes, and amine was studied in the presence of the Fe3O4@benzo[d]oxazole@Mn catalyst. The channelizer was then evaluated using various techniques. This catalyst can be recycled for seven consecutive periods.

Graphical Abstract

Magnetic Nanoparticles Functionalized with Benzo[d]oxazole as an Efficient and Recyclable Magnetic Catalyst for the Synthesis of 1,4-dihydropyridine Derivatives from Barbituric Acid

Keywords