Eco-Friendly Synthesis of 1,4-dihydropyridines Derivatives Using Fe3O4@Phen@Cu Magnetic Catalyst

Document Type : Original Research

Authors

1 Department of Organic Chemistry, Fudan University.

2 Department of Organic Chemistry, Faculty of Chemistry,Peking University.

Abstract

Among the most well-known MCRs is the Hantzsch reaction, which can synthesise 1,4-dihydropyridines (1,4-DHPs) with important biological and medicinal properties. Organic transformations, including the Hantzsch 1,4-dihydropyridine cycle, have been successfully promoted by magnetic catalysts in recent years. With the use of magnetic catalysts in water solution and at low temperatures, the production of 1,4-DHP and aromatization of these compounds can be carried out successfully. The purpose of this review is to highlight recent developments in the synthesis and aromatization of Hantzsch 1,4-DHPs using Fe3O4@Phen@Cu as a green approach. An SEM and FT-IR analysis were conducted on the catalyst to identify it. Nanoparticles are between 20 and 60 nanometers in size, according to the results. An environmentally friendly catalyst that is easily separated from the test environment by a magnet, this catalyst can be reused five times.

Graphical Abstract

Eco-Friendly Synthesis of 1,4-dihydropyridines Derivatives Using Fe3O4@Phen@Cu Magnetic Catalyst

Keywords