Aromatic Sulfonamides: S-N bond formation using MNPs-Benzo[d] imidazole-Cu Magnetic Catalyst

Document Type : Original Research

Authors

1 Institute of Chemical Nanotechnology and Material Science, Baghdad, Iraq.

2 Department of Chemistry, Analytical Chemistry, Baghdad, Iraq.

Abstract

A sulfonamide is an important scaffold in medicinal and synthetic organic chemistry, as it forms the basis of many sulfa drugs. Synthesis of sulfonamide has recently been made possible by the development of new methodologies. An aminosulfonylation of copper using aryldiazonium tetrafluoroborate, DABCO.(SO2)2, and N-chloroamines is described in this paper. Under mild conditions, this coupled reaction provides a simple and efficient method for preparing a wide range of sulfonamides. Based on a mechanistic investigation, this back-to-back reaction integrates radical catalysis and transition metal catalysis. The structure of MNPs-Benzo[d]imidazol-Cu nanocatalyst is well analyzed by several spectroscopic techniques. High reusability and good characterization of MNPs-Benzo[d]imidazol-Cu nanocatalyst, high purity and yields of products, aqueous conditions, and simple operation are several considerable advantages of this catalytic system. A magnet can be used to separate the synthesized catalyst and reuse it for six consecutive cycles.

Graphical Abstract

Aromatic Sulfonamides: S-N bond formation using MNPs-Benzo[d] imidazole-Cu Magnetic Catalyst

Keywords