A Straightforward and Effective Method has been Developed to Create a Magnetic Nano Catalyst Using Guanidine to the Convenient Synthesis of Aminopyrazole-4-carbonitriles through a one-pot, Three-Component Reaction in an Aqueous Environment

Document Type : Original Research

Authors

1 PhD, Allameh Tabataba’i University, cognitive sciences lab.

2 Department of Chemistry, Faculty of Basic Sciences, Payam Noor Varamin University

Abstract

The development of efficient and sustainable methods for the synthesis of organic compounds is of paramount importance in modern synthetic chemistry. Herein, we report the successful synthesis of a magnetic Nano catalyst employing guanidine as a key component. The magnetic Nano catalyst was prepared through a simple and straightforward procedure, enabling its easy fabrication and scalability. The developed magnetic Nano catalyst demonstrated remarkable catalytic activity in the synthesis of 5-aminopyrazole-4-carbonitriles, a class of important heterocyclic compounds with diverse applications in pharmaceuticals and materials science. Notably, the synthesis was achieved through a one-pot, three-component reaction conducted in an aqueous environment, ensuring environmental compatibility and minimizing waste generation. The magnetic Nano catalyst exhibited excellent reactivity and selectivity, leading to high yields of the desired aminopyrazole-4-carbonitrile products. Furthermore, the catalyst could be easily separated from the reaction mixture using an external magnet, allowing for efficient catalyst recovery and recycling. The use of guanidine as a key component in the magnetic Nano catalyst played a crucial role in enhancing catalytic performance. Guanidine, with its unique properties, facilitated the activation of reactants and provided a favorable environment for the formation of aminopyrazole-4-carbonitriles. Additionally, the magnetic nature of the Nano catalyst allowed for convenient manipulation during the reaction process. Overall, this study presents a novel and practical approach for the synthesis of 5-aminopyrazole-4-carbonitriles using a magnetic Nano catalyst prepared with guanidine. The developed method offers significant advantages in terms of simplicity, efficiency, and environmental friendliness, making it a valuable tool for the synthesis of diverse organic compounds with potential applications in various fields.

Graphical Abstract

A Straightforward and Effective Method has been Developed to Create a Magnetic Nano Catalyst Using Guanidine to the Convenient Synthesis of Aminopyrazole-4-carbonitriles through a one-pot, Three-Component Reaction in an Aqueous Environment

Keywords