A New and Green Method for the Synthesis of Spiro[indole‐quinazoline] Derivatives Using Magnetic Carbon Nitride Nanosheets of (SbCl3@Fe3O4 /g C3N4 ) as a Reusable Catalyst

Document Type : Original Research

Authors

1 Mumbai University Institute of Chemical Technology, India

2 Department of Chemistry, Mumbai University, India

Abstract

The development of efficient and environmentally friendly synthetic methodologies is of paramount importance in modern organic chemistry. Herein, we report a novel and green approach for the synthesis of spiro[indole‐quinazoline] derivatives using magnetic carbon nitride nanosheets functionalized with SbCl3@Fe3O4/g-C3N4 as a reusable catalyst. The synthesis of spiro[indole‐quinazoline] compounds is of significant interest due to their diverse biological activities and potential applications in drug discovery. However, conventional methods often suffer from several drawbacks, including the use of toxic reagents, harsh reaction conditions, and low yields. In this study, we successfully synthesized magnetic carbon nitride nanosheets by incorporating SbCl3@Fe3O4 nanoparticles onto g-C3N4 support. The resulting catalyst exhibited excellent magnetic properties, high stability, and superior catalytic activity. The unique combination of SbCl3 and Fe3O4 nanoparticles with g-C3N4 provided synergistic effects, enhancing the efficiency of the catalytic system. The developed methodology enabled the synthesis of spiro[indole‐quinazoline] derivatives through a one-pot multicomponent reaction involving isatin, dimedone, and guanidinium nitrate. The reaction proceeded smoothly under mild conditions, affording the desired products in good to excellent yields. 

Graphical Abstract

A New and Green Method for the Synthesis of Spiro[indole‐quinazoline] Derivatives Using Magnetic Carbon Nitride Nanosheets of (SbCl3@Fe3O4 /g C3N4 ) as a Reusable Catalyst

Keywords