Electro Organic Feist–Benary Reaction for the Synthesis of Some New Spiro Dihydrofuran Derivatives

Document Type : Original Research

Authors

Institute of Chemical Science and Nanotechnology, Delhi, India.

Abstract

Because of exhibition diverse pharmacological applications of benzofuran analogs in bioorganic, medicinal and pharmaceutical chemistry, a clean and efficient procedure was established to synthesize spiro benzofuran via one-pot, three-component reaction involve Michael addition, halogenation, and intramolecular ring-closing (MHIRC) reaction sequences. In this study two molecules of dimedone react with one molecule of isatin and malononitrile using ethanol in an undivided cell in the presence of sodium chloride results in highly efficient formation of spiro benzofuran with 86–93% substance yields.

Graphical Abstract

Electro Organic Feist–Benary Reaction for the Synthesis of Some New Spiro Dihydrofuran Derivatives

Keywords