An Efficient and Novel Method Catalyst for Synthesis of Warfarin Derivative Through One-Pot Pseudo Three-Component Reactions Using Alum as a Green Catalyst

Document Type : Original Research

Authors

Islamic Azad University Science and Research Branch, Tehran, Iran.

Abstract

Coumarins display a remarkable array of biochemical and pharmacological activities such as anticoagulant, anticancer, antioxidant, antiviral, anti-diabetic, anti-inflammatory, antibacterial, antifungal and anti-neurodegenerative. Warfarin derivatives are a valuable example of bioactive molecules containing coumarin structure that have many applications in medicinal chemistry. In this paper, the molecules of 4-hydroxycumarin, acetone, and aldehydes are combined in a single pot to form a pseudo three-component condensation that produces new warfarin derivatives in high yields with a fast reaction time. Alum, a non-toxic, reusable, affordable, and widely accessible reagent, served as the catalyst for this environmentally friendly protocol.

Graphical Abstract

An Efficient and Novel Method Catalyst for Synthesis of Warfarin Derivative Through One-Pot Pseudo Three-Component Reactions Using Alum as a Green Catalyst

Keywords