Novel and Simple Process for the Synthesis and Characterization of Gliclazide in the Presence of Sustainable Natural Deep Eutectic Solvents

Document Type : Short Communication

Author

Delhi university department of chemistry

Abstract

The synthesis of sulfonyl urea derivatives from p-toluene sulfonamide with various amines using carbonyl diimidazole natural deep eutectic solvents and catalyst was reported as a novel and simple process. To evaluate the reaction conditions, various aromatic, aliphatic, and heterocyclic amines were utilized. Most of the amines were well tolerated and formed their corresponding sulfonyl urea derivatives in good to better yields. A 92% yield was achieved in the synthesis of the anti-diabetic medication gliclazide using this approach. This approach is easy to use, has little reaction time, and doesn't require chromatographic purification.

Graphical Abstract

Novel and Simple Process for the Synthesis and Characterization of Gliclazide in the Presence of Sustainable Natural Deep Eutectic Solvents

Keywords