Copper (II) complex immobilized on magnetic nanoparticles catalyzed synthesis of oxazole and thiazole derivatives

Document Type : Original Research

Author

Institute of Chemical Science and Technology, Baghdad, Iraq

Abstract

During the last decade, nanomagnetic catalysts have attracted considerable attentions due to their simple recovery and reusability. Molecules with thiazole or oxazole ring are used as anti-virus, anti-tumor, anti-fungal, anti-bacterial and anti-cancer reagents. Up to now, many synthetic methodologies have been reported in the literature for the synthesis of oxazole and thiazole derivatives. In this research work, we reported that the utilization of Fe3O4@SiO2-Bipyridine-CuCl2 in EtOH under reflux conditions can be considered as a novel and ecofriendly catalytic system for the synthesis of oxazole and thiazole derivatives through the condensation of benzothioamide or benzamide with 2-bromoacetophenone derivatives. The recovered copper nanocatalyst could be reused 7 times without any significant loss of its activity.

Graphical Abstract

Copper (II) complex immobilized on magnetic nanoparticles catalyzed synthesis of oxazole and thiazole derivatives

Keywords